Cinci ani după evenimentele petrecute în prima serie, Ben Tennyson, în vârstă de 15 ani s-a întors la normal, la o viață obișnuită. Terminând cu aventurile sale, Ben și-a scos omnitrixul și a crescut de la un băiat mic într-un adolescent pe care te poți baza. Însă o nouă amenințare se apropie rapid de Pământ. O rasă de extratereștri parazită, Hibrizii, au ajuns în mod secret pe Pământ, cu intenția de a distruge omenirea. Max, bunicul lui Ben fiind un membru al organizației Instalatorilor, deja a pornit în călătoria de a încerca să-i oprească, dar de-atunci n-a mai fost văzut. Ben nu are de ales și trebuie să folosească încă o dată omnitrixul. Omnitrixul s-a contopit din nou cu corpul adolescentului, rezultând noi forme, funcții și extratereștri în care se poate transforma. Ben nu este singur. Verișoara lui, Gwen, i se alătură și ea, având puteri magice care au crescut semnificativ pe parcursul anilor. De asemenea, lui Ben i se alătură și rivalul său, Kevin Levin care și-a petrecut timpul în vidul nul. Pe parcursul seriei, Ben, Gwen și Kevin izgonesc hibrizii, se luptă cu inamici vechi și noi.

Lawrence, a traveling merchant searching for profit, finds a naked girl with the ears and tail of a wolf asleep in his cart. Her name is Holo – a harvest goddess with an untamed beast lurking inside who longs to return to her beloved northern home. Armed with his street smarts and her animal instincts, a simple peddler and a forgotten deity begin a journey through the wild countryside. Along their path, the riches of happiness shall be reaped, even as the bankruptcy which dwells in the human heart is exposed.

Koombaya, it's Eek the cat and all his friends. Annabelle, Eek's 800-pound girlfriend, Sharky the vicious but lovable sharkdog, and Elmo the elk. Plus you can watch the Terrible Thunderlizards try to make Bill and Scooter, the cavemen, extinct. Plus there's Klutter who's, well, we're not exactly sure what Klutter is, but watch and find out for yourself.

Masaru, is a second year Junior High student, and is undefeated in battle, He meets the Digital Monster Agumon, who has escaped from DATS, a secret government organization. Despite terrible first impressions, the two become best friends by talking with their "fists". With others, Masaru and Agumon work to investigate various incidents involving the Digital World and Digital Monsters, to try and get to the bottom of things.

Ginko, a Mushi master, travels from place to place researching the Mushi and helping people who are suffering because of it.

Aya Asagiri is a middle school girl who has problems both at school with bullying and at home from physical abuse by her brother. While browsing online, a website pops up on her computer featuring a creepy looking person. This person appears to take pity on her, and announces that she has granted Asagiri magical powers.

Set in a family restaurant in Hokkaido, the northern prefecture of Japan, 16-year-old high school student Sōta Takanashi works part-time along with his strange co-workers: Popura Taneshima, a high school girl who—despite being a year older than Sōta—is easily mistaken for a elementary/middle schooler, and Kyoko Shirafuji, the 28-year-old store manager who does not bother to do any work at all.

Shirou Emiya lost his parents in a fire when he was young and was later adopted by the sorcerer Kiritsugu Emiya. Shirou is drawn into the Holy Grail War summons a female "Servant" known as Saber to protect him and obtain the Holy Grail.

A teenage boy with accidental body enhancements fights the enemies of peace as a super-powered secret agent.

High school student Hiiragi Seiichi is bullied by his classmates for being a "loser." One day, his entire school is suddenly transported to a video game-like world of swords and sorcery. When he accidentally eats "the Fruit of Evolution," his life as a successful "winner" begins.

A typical morning. The usual music. Their normal lives. The peace these seven girls experience will suddenly be destroyed. By the living dead... zombies. A reality that they never wanted a part of, an amazing and terrifying zombie world. They all share one wish: "We want to live." These girls will struggle through this saga, in order to achieve a miracle.

Fear, survival, instinct. Thrown into a foreign land with nothing but hazy memories and the knowledge of their name, they can feel only these three emotions resonating deep within their souls. A group of strangers is given no other choice than to accept the only paying job in this game-like world—the role of a soldier in the Reserve Army—and eliminate anything that threatens the peace in their new world, Grimgar. When all of the stronger candidates join together, those left behind must create a party together to survive: Manato, a charismatic leader and priest; Haruhiro, a nervous thief; Yume, a cheerful hunter; Shihoru, a shy mage; Mogzo, a kind warrior; and Ranta, a rowdy dark knight. Despite its resemblance to one, this is no game—there are no redos or respawns; it is kill or be killed. It is now up to this ragtag group of unlikely fighters to survive together in a world where life and death are separated only by a fine line.

Touma, un tânăr cu puteri supranaturale, se aliază cu Index, o călugăriță, pentru a lupta contra forțelor răului care caută textele magice implantate în mintea acesteia.

After punching a famous curator in the face for criticizing his work as "textbook and lifeless," Handa Seishuu is sent to Gotō Island to calm his nerves and find new inspiration for his calligraphy. Growing up in the city all his life, though, Handa must adapt to country life while meeting an assortment of quirky people during his tenure.

Hiyori Iki is a normal middle school student until she was involved in a bus accident while trying to protect a stranger. This incident causes her soul to frequently slip out of her body, and she becomes aware of the existence of two parallel worlds. Through her soul, she meets the strange, nameless god without a shrine, Yato. Yato is determined to make a name for himself out there by accepting any wishes for 5 yen, including Hiyori's to fix her body.

Bobby Generic lives in a typical suburban neighborhood and uses his overactive imagination to discover a world of daring adventure, incredible wonder and lots of laughs — all in pint-sized perspective.

Ousai Academy is a former all-girls private high school which has recently been integrated for both genders. Takatoshi Tsuda is pushed into becoming the vice-president of the student council, where he is the lone male member surrounded by three beautiful girls.

Takamiya Honoka is a regular student whose only problem seems to be that he sits next to Kagari Ayaka, the school's #1 beauty. They have never spoken to each other before and any small interaction between them immediately results in her fanclub beating him. Yet when a falling part of the school's building is about to send him to the afterlife, it's Kagari that comes to his rescue. Only... she's dressed as a witch, carrying him in her arms and floating on a broom?! Kagari tells him it is her mission to protect him and that now she can finally protect him openly rather than undercover.

Mochizuki General Hospital boasts some of the most well-trained nurses in town. But though these ladies spend much of their day battling sickness, their after-hours are spent fighting a very different sort of disease... Under the leadership of the hospital chairman, a handful of staff members and local teenagers form a group of mercenary assassins, targeting the "cancers" of society and excising those individuals before their wickedness spreads.

The dark fantasy follows a high school sophomore named Akihito Kanbara. Although the boy appears human, he is half Youmu and invulnerable to wounds because he can heal quickly. One day, Akihito meets freshman Mirai Kuriyama when it seems she is about to jump from the school rooftop. Mirai is isolated because of her ability to manipulate blood, which is considered heresy among members of the spirit world. Disturbing events begin to unfold after Akihito saves Mirai.